The Centres for Disease Control and Prevention (CDC) recommend that all travellers are up-to-date with their routine vaccinations including; measles, mumps, rubella, diphtheria, tetanus, pertussis (whooping cough), hepatitis B, polio, influenza and pneumococcal disease. These vaccinations are given as part of the National Immunisation Program (NIP). For a full list please refer to the NIP schedule, available here. In some cases, you may need a booster or re-vaccination against a disease to ensure you still have immunity.
Travellers to South Africa who are aged 5 years or older should also ensure they are fully vaccinated against COVID-19.