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Which influenza strains have been recommended for Australian influenza vaccines in 2024?

The strains of influenza virus circulating in the population change and evolve over time.1 As a result, the composition of influenza vaccines is reviewed each year by the World Health Organisation (WHO) which makes recommendations on which strains of the influenza virus should be included in the following year’s vaccine.2

The WHO has now released their virus strain recommendations for the 2024 southern hemisphere influenza season and these have been approved by the Australian Therapeutic Goods Administration (TGA).2,3

The following strains are recommended for Australian influenza vaccines in 2024:2,3

Egg-based vaccines
an A/Victoria/4897/2022 (H1N1)pdm09-like virus*
an A/Thailand/8/2022 (H3N2)-like virus*
a B/Austria/1359417/2021 (B/Victoria lineage)-like virus
a B/Phuket/3073/2013 (B/Yamagata lineage)-like virus
Cell- or recombinant-based vaccines
an A/Wisconsin/67/2022 (H1N1)pdm09-like virus*
an A/Massachusetts/18/2022 (H3N2)-like virus*
a B/Austria/1359417/2021 (B/Victoria lineage)-like virus
a B/Phuket/3073/2013 (B/Yamagata lineage)-like virus

*Updated from the southern hemisphere influenza vaccine component in 2023.

How were this year’s recommendations made?

The WHO uses global influenza surveillance data to make influenza vaccine strain recommendations for the northern and southern hemispheres each year.4,5

Why are different strains recommended for egg-and cell-based vaccines?

Sometimes influenza viruses may not grow equally as well in egg- and cell- based vaccine production systems.4 When this is the case, different viruses with similar properties are sometimes recommended for the production of each vaccine type.4

 

How do these recommended strains differ from the northern hemisphere  2023–24 vaccine ?

The strain recommendations differ in the A(H3N2) vaccine virus component.

 A/Darwin/6/2021-like and A/Darwin/9/2021-like viruses were recommended for the 2023-2024 northern hemisphere A(H3N2) cell and egg-based vaccine  components, respectively. The 2024 southern hemisphere vaccine recommendation for the  A(H3N2) vaccine component is an A/Massachusetts/18/2022-like virus for cell-based and recombinant vaccines and A/Thailand/8/2022-like virus for egg-based vaccines.

What was Australia’s 2023 influenza season like?

Influenza season has been a bit different from usual over the past couple of years because the measures Australia took to prevent the spread of COVID-19 (like face masks , social distancing, lockdowns, and local and international travel restrictions) also helped to stop the spread of flu.6–8

As COVID-19 control measures relaxed, Australia experienced a predicted rebound in influenza cases during the 2022 season.9,10 In 2023, total influenza case numbers were similar to those of 2022 and peaked in June.11 Despite this, influenza vaccination rates were lower than previous years.12

 

Number of influenza cases reported in Australia by month and week of diagnosis, 2016–202311

Reported influenza cases in Australia 2017-2023

Source: Australian Government Department of Health and Aged Care Australian Influenza Surveillance Report.11

Despite total influenza notifications in 2023 being similar to 2022 notification numbers, vaccination rates were much lower sitting at 34%, almost 10% lower than in 2022 and at a similar level to 2021. 10-17

Influenza in Australia in 202310-17

  2021 
Influenza Season
2022 
Influenza Season
2023 
Influenza Season
Notifications 598 225,332 251,095
Influenza-related hospitalisations 1 1832 3,480
Influenza-related deaths 0 308 269
Population vaccinated (%) 34% 42% 34%

Since March 2021 vaccination providers have been required to record all influenza vaccines given and report these numbers to the Australian Immunisation Register (AIR).  This has been very valuable as it has given us more accurate data on influenza vaccine coverage across Australia.18

What can we expect in 2024?

It’s difficult to predict the severity of Australia’s 2024 influenza season. Some experts are predicting an early 2023-24 winter influenza season in the northern hemisphere - patterns observed abroad may be an early indicator of Australia's influenza activity next year, so protection is important. 19,20

Annual influenza  vaccination is still the simplest and most effective protection against influenza  and its complications.9  It’s important that you speak with your healthcare professional to discuss which influenza vaccine is most suitable for you.

In addition to vaccination, there are other important things you can do to reduce your chances of getting sick and passing influenza on to others:

  • wash your hands frequently and dry them properly
  • avoid people who are sneezing or coughing
  •  if you need to sneeze or cough, use a tissue and throw it out immediately afterwards
  •  if you are unwell, stay home.

Influenza can disrupt your life. There is a range of influenza vaccines available. Speak to your GP, pharmacist or nurse about which one is best for you.

Sources & Citations

  1. Centers for Disease Control and Prevention (CDC). Selecting Viruses for the Seasonal Influenza Vaccine. Available at: https://www.cdc.gov/flu/prevent/vaccine-selection.htm Accessed November 2023.
  2. World Health Organisation (WHO). Recommended composition of influenza virus vaccines for use in the 2024 southern hemisphere influenza season. Available at: https://www.who.int/publications/m/item/recommended-composition-of-influenza-virus-vaccines-for-use-in-the-2024-southern-hemisphere-influenza-season  Accessed October 2023.
  3. Australian Government Therapeutic Goods Administration. AIVC Recommendations for the Composition of Influenza Vaccines for Australia in 2024. Available at: https://www.tga.gov.au/resources/publication/meeting-statements/aivc-recommendations-composition-influenza-vaccines-australia-2024  Accessed October 2023.
  4. World Health Organisation (WHO). Questions and Answers (2023). Available at: https://cdn.who.int/media/docs/default-source/influenza/who-influenza-recommendations/vcm-southern-hemisphere-recommendation-2024/202309_qanda_recommendation.pdf?sfvrsn=7a6906d1_5 Accessed October 2023.
  5. World Health Organisation (WHO). Questions and Answers (2022). Available at: https://cdn.who.int/media/docs/default-source/influenza/who-influenza-recommendations/vcm-southern-hemisphere-recommendation-2022/202109_qanda_recommendation.pdf?sfvrsn=b9faa1cf_12  Accessed October 2023.
  6. Department of Health. National 2020 Influenza Season Summary. Available at: https://www1.health.gov.au/internet/main/publishing.nsf/Content/03943F9CD20D2CCCCA2586410078F296/$File/National-Influenza-Season-Summary2020.pdf Accessed October 2023.
  7. Department of Health. Australian Influenza Surveillance Report - 2021 Influenza Season in Australia. Available at: https://www1.health.gov.au/internet/main/publishing.nsf/Content/cda-surveil-ozflu-flucurr.htm#:~:text=Influenza%2Dlike%2Dillness%20(ILI,remained%20low%20since%20April%202020  Accessed October 2023.
  8. Koutsakos M et al. Nat Rev Microbiol 202;19(12):741–2.
  9. Australian Technical Advisory Group on Immunisation (ATAGI). Statement on administration of seasonal influenza vaccines in 2023. Available at: https://www.health.gov.au/sites/default/files/2023-06/atagi-advice-on-seasonal-influenza-vaccines-in-2023_0.pdf  Accessed October 2023.
  10. Australian Government Department of Health and Aged Care. Australian Influenza Surveillance Report - No 14 - fortnight ending 09 October 2022. Available at: https://www1.health.gov.au/internet/main/publishing.nsf/Content/B4F29E7D594818EBCA2588DB000EA9D2/$File/flu-14-2022.pdf. Accessed October 2023.
  11. Australian Government Department of Health and Aged Care. Australian Influenza Surveillance Report - No 14 - fortnight ending 15 October 2023. Available at:  https://www.health.gov.au/sites/default/files/2023-10/aisr-fortnightly-report-no-14---02-october-to-15-october-2023.pdf . Accessed October 2023.
  12. Australian Government Department of Health and Aged Care. Influenza (flu) immunisation data – 1 March to 3 October 2023. Available at: https://www.health.gov.au/sites/default/files/2023-10/influenza-flu-immunisation-data-1-march-to-3-october-2020-2023.pdf  Accessed October 2023.
  13. Sanofi Data on File.
  14. Australian Government Department of Health and Aged Care. Influenza (flu) immunisation data – 1 March 2022 to 9 October 2022. Available at: https://www.health.gov.au/sites/default/files/documents/2022/10/influenza-flu-immunisation-data-1-march-to-9-october.pdf, Accessed October 2023.
  15. Australian Government Department of Health. Influenza (flu) immunisation data – 1 November 2021. Available at: https://www.health.gov.au/sites/default/files/documents/2021/11/influenza-flu-immunisation-data-influenza-flu-immunisation-data-1-november-2021.pdf. Accessed October 2023.
  16. Australian Bureau of Statistics. National, state and territory population. Available at: https://www.abs.gov.au/statistics/people/population/national-state-and-territory-population/mar-2022. Accessed October 2023.
  17. Australian Government Department of Health. Australian Influenza Surveillance Report - No 16  - fortnight ending 07 November 2021. Available at: https://www1.health.gov.au/internet/main/publishing.nsf/Content/018A35D7E15F04C0CA25878D0078D70B/$File/flu-16-2021.pdf. Accessed October 2023.
  18. Australian Government Department of Health and Aged Care. Mandatory reporting of National Immunisation Program vaccines to the Australian Immunisation Register began on 1 July 2021. Available at: https://www.health.gov.au/news/mandatory-reporting-of-national-immunisation-program-vaccines-to-the-australian-immunisation-register-began-on-1-july-2021. Accessed November 2023.
  19. Medical Xpress. Flu season started early in Australia—countries in the northern hemisphere took note. Available at: https://medicalxpress.com/news/2023-09-flu-season-early-australiacountries-northern.html Accessed October 2023
  20. Nazareth J et al. Lancet Infect Dis 2022;22(9):1280–81.

MAT-AU-2302543 v1. Date of approval November 2023.